What is the monograph dose for psychosis for brexpiprazole (daily, in mg)?

What is the monograph dose for psychosis for brexpiprazole (daily, in mg)?

• A. 1-2 mg
• B. 2-4 mg
• C. 3-5 mg
• D. 4-6 mg

Answer: (B)

Brexpiprazole for psychosis in schizophrenia is started at a low dose and then titrated to a practical maintenance range. In drug monographs, the usual daily dose is 2 to 4 mg once daily, with 1 mg daily often used at the start and adjusted up to reach the target range. The maximum recommended dose is 4 mg daily. This is why the appropriate monograph dose is 2-4 mg daily. Doses higher than this (and especially at 5 mg or 6 mg) aren’t recommended due to a greater risk of adverse effects, while doses below this range may be subtherapeutic for many patients. The 2-4 mg window balances efficacy as a D2 receptor partial agonist with tolerability in most patients.

Brexpiprazole for psychosis in schizophrenia is started at a low dose and then titrated to a practical maintenance range. In drug monographs, the usual daily dose is 2 to 4 mg once daily, with 1 mg daily often used at the start and adjusted up to reach the target range. The maximum recommended dose is 4 mg daily. This is why the appropriate monograph dose is 2-4 mg daily. Doses higher than this (and especially at 5 mg or 6 mg) aren’t recommended due to a greater risk of adverse effects, while doses below this range may be subtherapeutic for many patients. The 2-4 mg window balances efficacy as a D2 receptor partial agonist with tolerability in most patients.